Improvement of the Fermentation Productivity of a New Antibiotic AGPM by Orthogonal Design Experiment
抗生素AGPM摇瓶发酵条件的正交实验

The effects of medium composition on the activity of a new antibiotic APGM was studied by orthogonal design experiment. It seems that nitrogen source presented the most significant effect on the production of AGPM and that higher ratio of carbon to nitrogen was beneficial. It was concluded that the fermentation activity was increased by 18.9 times to 1562.2 u/ml under the optimal conditions as the medium was composed of glucose 5 g/L,corn starch 40 g/L, soybean meal 16 g/L, corn steep liqour 2 ml, K2HPO4 1.0 g/L, MgSO4?H2O 0.5 g/L, NaCl 0.5 g/L and amylase 0.05 g/L.