Progress in the study of Ser/Thr kinase Plk1
丝/苏氨酸蛋白激酶Plk1研究进展

Polo-like kinase 1(Plk1) play critical roles during multiple stages of cell cycle progression. Plk1 contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains two Polo-boxes. Plk1 gene and protein expression has been proposed as a new prognostic marker for many types of malignancies, and Plk1 is a potential target for cancer therapy.