The Action of Protease Activating factor Apaf-2/CytC on Apoptosis
关键蛋白酶激活因子Apaf-2/CytC在细胞凋亡中的作用

The action of Apaf-2/CytC on apoptosis was described. It has mainly set forth the discovery of apoptosis-correlation element Apaf-2/CytC, the action of Apaf-2,Apaf-1 and Apaf-3 on apoptosis and their relations, the manner of CytC mediating the apoptosis. It has also discussed the mechanism of CytC leakage in the mitochondria, and set forth the MPTP hypothesis, specific tunnel hypothesis and mitochondria swelling. It has analyzed the signal transferring pathway of Apaf-2/CytC-mediated apoptosis, such as CytC pathway, Fas/FasL pathway, protein kinase pathway, apoptosis inducing factor pathway and their cross talking. Finally, it has analyzed the meaning of studying the molecular mechanism of CytC-mediated apoptosis, and put forward the problem existed in the research of molecular mechanism of apoptosis.