%0 Journal Article
%T The Action of Protease Activating factor Apaf-2/CytC on Apoptosis<br>关键蛋白酶激活因子Apaf-2/CytC在细胞凋亡中的作用
%A CHEN Rong-lin
%A LI Hong
%A LIU Jian-hui
%A <br>陈荣林
%A 李宏
%J 中国生物工程杂志
%D 2006
%I 
%X The action of Apaf-2/CytC on apoptosis was described. It has mainly set forth the discovery of apoptosis-correlation element Apaf-2/CytC, the action of Apaf-2,Apaf-1 and Apaf-3 on apoptosis and their relations, the manner of CytC mediating the apoptosis. It has also discussed the mechanism of CytC leakage in the mitochondria, and set forth the MPTP hypothesis, specific tunnel hypothesis and mitochondria swelling. It has analyzed the signal transferring pathway of Apaf-2/CytC-mediated apoptosis, such as CytC pathway, Fas/FasL pathway, protein kinase pathway, apoptosis inducing factor pathway and their cross talking. Finally, it has analyzed the meaning of studying the molecular mechanism of CytC-mediated apoptosis, and put forward the problem existed in the research of molecular mechanism of apoptosis.
%K Apaf-2/CytC<br>细胞凋亡途径
%K 线粒体
%K 泄漏
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=AA60794AF90BBBD1&yid=37904DC365DD7266&vid=96C778EE049EE47D&iid=38B194292C032A66&sid=CFAC5CB624A41AFD&eid=08805F9252973BA4&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=1&reference_num=16