Relationship between the Bioactivity of BMP2/7 Heterodimers and its Regulation of CIZ Expression
BMP2/7异源二聚体调控CIZ的表达与自身活性的关系

BMP2/7 heterodimer has stronger bioactivity than BMP2 homodimer,but the mechanism remains to be unclear.Treating the osteoblast MC3T3-E1 cells with BMP proteins,results of Alkalin phosphatase staining,Alizarin red staining,as well as p3GC2-LUX luciferase assay demonstrated that BMP2/7 heterodimers significantly promoted osteogenic differentiation to a higher extent than BMP2 homodimers.Overexpression of CIZ in MC3T3-E1 significantly inhibited the promotion of ALP and Osteocalcin expression by BMP2/7,and blocked activation of BMP/Smad.BMP protein may induce the expression of CIZ,but effects of BMP2/7 heterodimer is weaker than BMP2 homodimer.It suggests that the effects of BMP2/7 on CIZ expression is related to its bioactivity.