%0 Journal Article
%T Relationship between the Bioactivity of BMP2/7 Heterodimers and its Regulation of CIZ Expression<br>BMP2/7异源二聚体调控CIZ的表达与自身活性的关系
%A PAN Qiu-hui
%A YANG Song-hai
%A DONG Qun-wei
%A SUN Fen-yong
%A <br>潘秋辉
%A 杨松海
%A 董群伟
%A 孙奋勇
%J 中国生物工程杂志
%D 2007
%I 
%X BMP2/7 heterodimer has stronger bioactivity than BMP2 homodimer,but the mechanism remains to be unclear.Treating the osteoblast MC3T3-E1 cells with BMP proteins,results of Alkalin phosphatase staining,Alizarin red staining,as well as p3GC2-LUX luciferase assay demonstrated that BMP2/7 heterodimers significantly promoted osteogenic differentiation to a higher extent than BMP2 homodimers.Overexpression of CIZ in MC3T3-E1 significantly inhibited the promotion of ALP and Osteocalcin expression by BMP2/7,and blocked activation of BMP/Smad.BMP protein may induce the expression of CIZ,but effects of BMP2/7 heterodimer is weaker than BMP2 homodimer.It suggests that the effects of BMP2/7 on CIZ expression is related to its bioactivity.
%K Bone morphogenetic protein Heterodimer Osteoblast Differentiation CIZ protein<br>骨形态发生蛋白
%K 异源二聚体
%K 成骨细胞
%K 分化
%K CIZ蛋白
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=951380788B355DEA7D75520FA3B199C9&aid=FFB7AC93596B465D&yid=A732AF04DDA03BB3&vid=DB817633AA4F79B9&iid=9CF7A0430CBB2DFD&sid=F3583C8E78166B9E&eid=13553B2D12F347E8&journal_id=1671-8135&journal_name=中国生物工程杂志&referenced_num=1&reference_num=11