AN NMR STUDY OF DEXAMETHASONE PALMITATE
地塞米松棕榈酸酯的NMR数据解析

Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting anti-inflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (~1H, ~(13)C NMR and DEPT) and 2D (~1H-~1HCOSY,HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ~1H and ~(19)F NMR spectra of dexamethason in the aqueous solution, the standard ~1H and ~(13)C NMR spectra of palmitate and the Lindeman-Adams experimental formula.