%0 Journal Article
%T AN NMR STUDY OF DEXAMETHASONE PALMITATE<br>地塞米松棕榈酸酯的NMR数据解析
%A ZHANG Hai-yan
%A <br>张海艳
%A 吴鸣建
%A 董建军
%A 付经国
%A 陈涛
%A 赵天增
%J 波谱学杂志
%D 2004
%I 
%X Dexamethasone palmitate incorporated into liposomes (liposteroid) was developed as a targeting anti-inflammatory drug (limethason) used mainly for treatment of rheumatoid arthritis. In this study, 1D (~1H, ~(13)C NMR and DEPT) and 2D (~1H-~1HCOSY,HMQC and HMBC) NMR spectra of dexamethasone palmitate in chloroform were obtained, assigned and analyzed. The structure of dexamethasone palmitate in chloroform was elucidated by referring to the ~1H and ~(19)F NMR spectra of dexamethason in the aqueous solution, the standard ~1H and ~(13)C NMR spectra of palmitate and the Lindeman-Adams experimental formula.
%K NMR
%K 2D NMR<br>归属
%K 地塞米松棕榈酸酯
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=47EA7CFDDEBB28E0&jid=1A3C8C6E452BD1AF5A6B6B99BA3989C9&aid=A8EE50F9357ECB96&yid=D0E58B75BFD8E51C&vid=659D3B06EBF534A7&iid=E158A972A605785F&sid=EB58C3052341AAA3&eid=34D9E20AD82A0D72&journal_id=1000-4556&journal_name=波谱学杂志&referenced_num=0&reference_num=18