Studies on the chemical constituents and bioactivities of five schisandra medicinal species and elsholtzia bodinieri
五种五味子属药用植物及东紫苏的化学成分和生物活性研究

The chemical constituents and bioactivities of six medicinal plants have been studied. In the study, one hundred and one compounds, including twenty-six new compounds were isolated. Among these compounds, sixteen unique highly oxidized nortriterpenoids, belonging to an unprecedented new nortriterpenoid skeleton with a biosynthetically modified eight-membered ring, and unusual nortriterpenoids or bisnortriterpenoid skeletons, have been isolated from three Schisandra species. Interestingly, to date, no naturally occurring triterpenoids have been found to have such a highly modified oxidized norcycloartane skeleton. The bioactivities of compounds isolated from the genus Schisandra have been tested, including anti-HIV-1, anti-inflammatory, and cytotoxities against C8166, MT-4 and K562 cells activities. Gomisin G and micrandilactone C were found to show promising anti-HIV-1 activity and the selectivity index were 174.08 and >25.94, respectively.