%0 Journal Article
%T Studies on the chemical constituents and bioactivities of five schisandra medicinal species and elsholtzia bodinieri<br>五种五味子属药用植物及东紫苏的化学成分和生物活性研究
%A LI Rong-Tao
%A SUN Han-Dong
%A <br>李蓉涛
%A 孙汉董
%J 中国科学院研究生院学报
%D 2008
%I 
%X The chemical constituents and bioactivities of six medicinal plants have been studied. In the study, one hundred and one compounds, including twenty-six new compounds were isolated. Among these compounds, sixteen unique highly oxidized nortriterpenoids, belonging to an unprecedented new nortriterpenoid skeleton with a biosynthetically modified eight-membered ring, and unusual nortriterpenoids or bisnortriterpenoid skeletons, have been isolated from three Schisandra species. Interestingly, to date, no naturally occurring triterpenoids have been found to have such a highly modified oxidized norcycloartane skeleton. The bioactivities of compounds isolated from the genus Schisandra have been tested, including anti-HIV-1, anti-inflammatory, and cytotoxities against C8166, MT-4 and K562 cells activities. Gomisin G and micrandilactone C were found to show promising anti-HIV-1 activity and the selectivity index were 174.08 and >25.94, respectively.
%K Schisandra species
%K Elsholtzia bodinieri
%K chemical constituents
%K anti-HIV activity
%K biogenetic origin<br>五味子属
%K 东紫苏
%K 化学成分
%K 抗HIV活性
%K 生源途径
%K Schisandra
%K species
%K Elsholtzia
%K bodinieri
%K chemical
%K constituents
%K anti-HIV
%K activity
%K biogenetic
%K origin
%K 五味子
%K 药用植物
%K 东紫苏
%K 化学成分
%K 生物活性
%K Elsholtzia
%K bodinieri
%K species
%K bioactivities
%K chemical
%K constituents
%K show
%K promising
%K activity
%K selectivity
%K index
%K cells
%K genus
%K triterpenoids
%K date
%K skeleton
%K modified
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=B5EDD921F3D863E289B22F36E70174A7007B5F5E43D63598017D41BB67247657&cid=B47B31F6349F979B&jid=67CDFDECD959936E166E0F72DE972847&aid=DEB3FA678C7ED8451FA1DD40CC39EAAD&yid=67289AFF6305E306&vid=C5154311167311FE&iid=E158A972A605785F&sid=1FA4E9C3E6E88FC8&eid=E406B4E9A1BA9D8C&journal_id=1002-1175&journal_name=中国科学院研究生院学报&referenced_num=0&reference_num=16