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中国科学 生命科学 2010
Implication of heparan sulfate proteoglycans in diseases
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Abstract:
Heparan sulfate proteoglycan (HSPG),a group of macromolecular glycoconjugates expressed on the cell surfaces and in the extracellular matrix (ECM),is essential for animal development and homeostasis.HSPG participates in many important biological activities,mostly through interactions of the side heparan sulfate (HS) polysaccharide chains with a wide range of protein ligands.Cell surface HS interacts with growth factors and their receptors,mediating signal transduction.As a main component of the ECM,HSPG mai...