Studies of Tubulin Polymerization in vitro Affected by Thiabendazole
2（4′噻唑）苯丙咪唑对猪脑微管蛋白体外聚合的影响 Studies of Tubulin Polymerization in vitro Affected by Th iabendazole

Tubulin isolated from porcine brain was employed in the experiment to study the mechanism of aneuploidy induced by thiabendazole(TBZ) by analyzing the polymerization of tubulin. Colchicine was set as a positive control of the experiment. The experiment indicated that TBZ could inhibit the tubulin polymerization significantly and showed a dose effect relationship. The result suggested that TBZ may induce aneuploidy by the pathway of tubulin polymerization inhibition which is able to lead to chromosomal malsegregation.