%0 Journal Article
%T Studies of Tubulin Polymerization in vitro Affected by Thiabendazole<br>2（4′噻唑）苯丙咪唑对猪脑微管蛋白体外聚合的影响 Studies of Tubulin Polymerization in vitro Affected by Th iabendazole
%A SONG Zhong kui
%A LIANG Zi qing
%A WANG Xu
%A <br>宋忠魁
%A 梁子卿
%A 汪旭SONG Zhong-kui
%A LIANG Zi-qing
%A WANG Xu
%J 遗传
%D 2001
%I 
%X Tubulin isolated from porcine brain was employed in the experiment to study the mechanism of aneuploidy induced by thiabendazole(TBZ) by analyzing the polymerization of tubulin. Colchicine was set as a positive control of the experiment. The experiment indicated that TBZ could inhibit the tubulin polymerization significantly and showed a dose effect relationship. The result suggested that TBZ may induce aneuploidy by the pathway of tubulin polymerization inhibition which is able to lead to chromosomal malsegregation.
%K thiabendazole
%K tubulin polymerization
%K aneuploidy<br>苯丙咪唑
%K 微管蛋白聚合
%K 非整倍体
%K 猪
%K 脑
%K 诱变作用
%K 药物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=04E7B822D3FB7DDC98B349C4A63160EC&yid=14E7EF987E4155E6&vid=EA389574707BDED3&iid=38B194292C032A66&sid=334E2BB8B9A55ABB&eid=AA27B676BFCAA4BE&journal_id=0253-9772&journal_name=遗传&referenced_num=0&reference_num=2