Study on Familial Aggregation of Lung Cancer Among Women in Shanghai
上海市区女性肺癌的家族聚集性研究 Study on Familial Aggregation of Lung Cancer Among Women in Shanghai

The data set of a large population-based case-control study of female lung cancer conducted in Shanghai urban was used to investigate the contribution of lung cancer in first-degree relatives to lung cancer risk. The analysis in the paper is emphasised on non-smoking women. The results indicates that the risk of first-degree relatives with lung cancer is increased about 3-fold (OR=2.80, 95% CI 1.68-4.67), and for non-smoking probands the OR is 2.62 (95% CI 1 .52-4.52). The odds ratios of adeno-carcinoma, squamous cell carcinoma, orthers unknown of lung cancer are 2.79 (95% CI : 1.53-5.10), 3.88 (95% CI:1.42-10.63), 1.26(95%CI: 0.27-6.01), 2.52 (95% CI : 1.16-5.49),respectively. For cases of age groups of 35 to 59 and 60 to 69 years of probands, with ORs of 4.01 (95% CI: 1 .79-8.97)and 1 .89 (95% CI: 0.89-3.98) respectively. The odds ratio from multivariable unconditional logistic regression is 2.71 (95% CI: 1.54-4.76). The estimation of adjusted population attributable risk is 5.31% based on the multivariable logishc regression model analysis.