%0 Journal Article
%T Study on Familial Aggregation of Lung Cancer Among Women in Shanghai<br>上海市区女性肺癌的家族聚集性研究 Study on Familial Aggregation of Lung Cancer Among Women in Shanghai
%A Xiang Yongbing
%A Gao Yutang
%A Zhong Lijie
%A Jin Fan
%A Sun Lu
%A Cheng Jiarong
%A <br>项永兵
%A 高玉堂
%A 钟礼杰
%A 金凡
%A 孙璐
%A 程家蓉XIANG Yong-Bing
%A GAO Yu-Tang
%A ZHONG Li-Jie
%A JIN Fan
%A SUN Lu
%A CHENG Jia-Rong
%J 遗传
%D 1996
%I 
%X The data set of a large population-based case-control study of female lung cancer conducted in Shanghai urban was used to investigate the contribution of lung cancer in first-degree relatives to lung cancer risk. The analysis in the paper is emphasised on non-smoking women. The results indicates that the risk of first-degree relatives with lung cancer is increased about 3-fold (OR=2.80, 95% CI 1.68-4.67), and for non-smoking probands the OR is 2.62 (95% CI 1 .52-4.52). The odds ratios of adeno-carcinoma, squamous cell carcinoma, orthers unknown of lung cancer are 2.79 (95% CI : 1.53-5.10), 3.88 (95% CI:1.42-10.63), 1.26(95%CI: 0.27-6.01), 2.52 (95% CI : 1.16-5.49),respectively. For cases of age groups of 35 to 59 and 60 to 69 years of probands, with ORs of 4.01 (95% CI: 1 .79-8.97)and 1 .89 (95% CI: 0.89-3.98) respectively. The odds ratio from multivariable unconditional logistic regression is 2.71 (95% CI: 1.54-4.76). The estimation of adjusted population attributable risk is 5.31% based on the multivariable logishc regression model analysis.
%K Lung cancer
%K Faimilial aggregation
%K Case-control study
%K Genetic epidemiology<br>肺癌
%K 家族聚集性
%K 病例对照研究
%K 遗传流行病学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=3E23F50E071DF18E21B2F5AEE4F1FA5E&aid=2F3F9D1C0B064B8D94C94AB65B6F5230&yid=8A15F8B0AA0E5323&vid=13553B2D12F347E8&iid=94C357A881DFC066&sid=4AD960B5AD2D111A&eid=6209D9E8050195F5&journal_id=0253-9772&journal_name=遗传&referenced_num=9&reference_num=6