Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness
三例氨基糖甙类抗生素致聋患者的线粒体DNA测序分析 Mitochondria DNA Sequence Analysis of 3 Cases with Aminoglycoside Antibiotics Induced Deafness

The mitochondria DNAs (mtDNAs) of thrce patients with AAID were analysed using the method of direct sequeneing of their PCR produets. The results showed that all their mtDNAs had an A-G mutation at nucleotides 1 555. It is considered that this mutation is the molecular basis causing human susceptibility to Aminoglycoside Antibiotics toxicity which in coopcration with Aminoglycoside Antibiotics results in deafness.