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遗传 1996
Effect of Anticancer Drugs on Nuclear Damage in Lymphocytes and Germ Cells of Periplaneta fulginosa
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Abstract:
0.1%, 0.3%, 0.5%Thio-TEPA induced 6.3%, 10.5% and 14.2% chromosome break or gap in spermatocyte of coockroach respectively. This was markedly higher than those in oocyte. In doses from 0.1 to 0.5 Tho-TEPA the frequency of micronucleus increased parallely with nuclear damage.0.1 %, 0.3%,0.5% 5-fluorouracil induced 3.5%, 9.8%, 16.2% chromosome break or gap in oocytes respectively. This was paralled with the frequency of micronllcleus in lymphocytes of the female. 5-fluorouracil showed not marked effect on spermatocyte.
