Metabolic engineering strategies for carboxylic acids production by Saccharomyces cerevisiae---a review
酿酒酵母生产羧酸的代谢工程策略

Carboxylatic acids have been widely used in food,pharmaceutical and chemical industries.As a eukaryotic model organism,Saccharomyces cerevisiae is thought as cell factory to produce organic acids through manipulating metabolic pathway.In this review,we addressed the metabolic engineering strategies to construct a high titer route converting pyruvate to target carboxylate,and to explore how to divert the carbon flux to desired product from ethanol.Furthermore,we also discussed the mechanisms for carboxylate ...