Breeding of High Streptolydigin-Producing Strain by Complex Mutagenesis and Resistance Selection
复合诱变和抗性筛选利迪链菌素高产菌株

为解决利迪链霉菌生产能力低的问题，以Streptomyces lydicus AS 4.2501-P28为出发菌株，应用紫外和吖啶橙诱变，结合抗生素的抗性筛选，得到稳定高产的S. lydicus AS 4.2501-L8，发酵水平达到177.0 μg/mL，较出发菌株提高了96.2%。