Analysis of Tetracycline-Resistant Aeromonas hydrophlia by Proteome Techniques
嗜水气单胞菌耐四环素的蛋白质组学初步研究

In the article, the tetracycline-resistant Aeromonas hydrophlia was selected with antibiotic sub-inhibitory concentration of tetracycline. MIC of the resistant strains was eight times the original strains. To compare with 2-D PAGE of original strains, three proteins were achieved expressing conspicuous variances in resistant strains. By MALDI-TOF-MS and the Peptident software in the SWISS-PROT database, the variances were analyzed and elementarily identified as relevant with ribosomal small unit proteins, drug-discharged system proteins and acetate CoA-transferase beta subunit respectively. Besides, the resistant mechanism of Aeromonas hydrophlia was elementarily studied.