Differential Expression of Human Macrophage Genes Encoding Cytokines and Their Regulatory Elements After Mycobacterium tuberculosisInfection
结核分枝杆菌感染诱导的人巨噬细胞细胞因子及其调控基因的差异表达谱

To investigate whether the genes encoding cytokines and their regulatory element s participated in the immune response to \%Mycobacterium tuberculosis\% infectio n. Expression microarray was employed to compare the avirulent strain and clinic ally isolated strains infection induced macrophage c ytokine differential expression. Results were cytokines IFN, TNF,TGF, IL and the ir regulatory elements are involved in the immune reaction. IL-19 was first rep orted to be involved in the anti-Mtb immunity. Relative expression level of the ses factors before and after infection were assayed too.The data provides clues for further scrutinize the role of cytokines and related elements in the i nteraction between \%Mycobacterium tuberculosis\% and host macrophage.