%0 Journal Article
%T Differential Expression of Human Macrophage Genes Encoding Cytokines and Their Regulatory Elements After Mycobacterium tuberculosisInfection<br>结核分枝杆菌感染诱导的人巨噬细胞细胞因子及其调控基因的差异表达谱
%A Xie Jianping
%A Li Yao
%A Yue Jun
%A Xu Yongzhong Wang Honghai
%A <br>谢建平
%A 李瑶
%A 乐军
%A 徐永忠
%A 王洪海
%J 微生物学报
%D 2003
%I 
%X To investigate whether the genes encoding cytokines and their regulatory element s participated in the immune response to \%Mycobacterium tuberculosis\% infectio n. Expression microarray was employed to compare the avirulent strain and clinic ally isolated strains infection induced macrophage c ytokine differential expression. Results were cytokines IFN, TNF,TGF, IL and the ir regulatory elements are involved in the immune reaction. IL-19 was first rep orted to be involved in the anti-Mtb immunity. Relative expression level of the ses factors before and after infection were assayed too.The data provides clues for further scrutinize the role of cytokines and related elements in the i nteraction between \%Mycobacterium tuberculosis\% and host macrophage.
%K Cytokines
%K Expression microarray
%K Macrophage U937
%K My cobacterium tuberculosis<br>细胞因子，结核分枝杆菌，巨噬细胞，表达谱芯片
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=9B694B3252A65C94&yid=D43C4A19B2EE3C0A&vid=BE33CC7147FEFCA4&iid=94C357A881DFC066&sid=06D504E5261AB652&eid=42FF82ADD37D41AA&journal_id=0001-6209&journal_name=微生物学报&referenced_num=0&reference_num=21