THE EPOXIDATION OF cis-PROPENYLPHOPHONIC ACID TO FOSFOMYCIN BY PENCILLIUM SP.
青霉菌立体选择性环氧化顺丙烯磷酸产生磷霉素

One strain of Penicillium sp. F5, found from soil sample, was able to stereo-specific epoxidation of cis-propenylphosphonic acid(PPOH) to fosfomycin(-)-(1R, 2S)-1, 2-epoxypropylphosphonic acid, FOM] during the cultivation. The product (FOM) was identified by thin layer chromatography and microbiological assay. Under the culture conditions of 28 degrees C pH7.5 and 280 r/min, 0.3% concentration of PPOH, reached a level of 2.2 mg/ml of FoM and the yield was 41%. When the PPOH concentration was 0.6%, the yield was 8%.