%0 Journal Article
%T THE EPOXIDATION OF cis-PROPENYLPHOPHONIC ACID TO FOSFOMYCIN BY PENCILLIUM SP.<br>青霉菌立体选择性环氧化顺丙烯磷酸产生磷霉素
%A Shi Jiaji Cui Fumian Ge meng
%A <br>石家骥
%A 崔福绵
%A 葛猛
%J 微生物学报
%D 2001
%I 
%X One strain of Penicillium sp. F5, found from soil sample, was able to stereo-specific epoxidation of cis-propenylphosphonic acid(PPOH) to fosfomycin(-)-(1R, 2S)-1, 2-epoxypropylphosphonic acid, FOM] during the cultivation. The product (FOM) was identified by thin layer chromatography and microbiological assay. Under the culture conditions of 28 degrees C pH7.5 and 280 r/min, 0.3% concentration of PPOH, reached a level of 2.2 mg/ml of FoM and the yield was 41%. When the PPOH concentration was 0.6%, the yield was 8%.
%K Penicillium
%K sp
%K Cis\|propenylphophonic acid
%K Fosfomycin
%K Biotransformation<br>青霉
%K 顺丙烯磷酸
%K 磷霉素
%K 生物转化
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A3C6BA55AB623B90FA9104CFFC826F3C&aid=FF9122E263FB6F4B&yid=14E7EF987E4155E6&vid=2001E0D53B7B80EC&iid=38B194292C032A66&sid=A5111BA190517959&eid=35E8A259891FB32F&journal_id=0001-6209&journal_name=微生物学报&referenced_num=7&reference_num=7