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OALib Journal期刊
ISSN: 2333-9721
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Preparation of Chiral Alcohol by Stereoselective Reduction of Acetophenone and Chloroacetophenone with Yeast Cells
微生物法还原氯代苯乙酮制备手性醇

Keywords: Chloroacetophenone,Stereoselective reduction,Chiral alcohol
氯代苯乙酮,选择性还原,手性醇

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Abstract:

Four strains of microorganisms which have activity of chloroacetophenone reduction were screened, in which Saccharomyces cerevisiae B5 showed the highest activity and good stereoselectivity. This strains showed different activity on the reduction of various substrates in the following order: 2'-chloroacetophenone > 2-chloromethylacetophenone > 4'-chloroacetophenone > 3'-chloroacetophenone > acetophenone. Ethanol is the best cosubstrate and its optimal concentration is 5%.

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