The measures of avoiding complement attack in Baculovirus-mediated gene delivery
杆状病毒介导的基因传递逃避补体攻击的措施

Serum complement system is the signiflcant barrier to the development of bacu-lovirus vectors for therapeutic gene delivery.This paper gave a review to the efforts taken to avoid complement attack.Selecting the immunoprivileged tissues as target for baculovi-rus-mediated gene delivery,such as eye,brain and testis.ex vivo transduction is a widely used approach to exclude the complement attack.Using of pharmacological inhibitors of comple-ment as well as surface engineering of the baculoviral vectors through the use of synthetic polymers,pseudotyping or display of complement inhibitors can inhibit complement attack ef-ficiently.This will signiflcantly increase the possibility of using baculovirus vectors for thera-peutic applications.