%0 Journal Article
%T The measures of avoiding complement attack in Baculovirus-mediated gene delivery<br>杆状病毒介导的基因传递逃避补体攻击的措施
%A WAN Jing
%A ZHOU Xiang-yang
%A ZHOU Xiu-jin
%A SHAO hong-hong
%A <br>万婧
%A 周向阳
%A 周秀锦
%A 邵宏宏
%J 微生物学通报
%D 2012
%I 
%X Serum complement system is the signiflcant barrier to the development of bacu-lovirus vectors for therapeutic gene delivery.This paper gave a review to the efforts taken to avoid complement attack.Selecting the immunoprivileged tissues as target for baculovi-rus-mediated gene delivery,such as eye,brain and testis.ex vivo transduction is a widely used approach to exclude the complement attack.Using of pharmacological inhibitors of comple-ment as well as surface engineering of the baculoviral vectors through the use of synthetic polymers,pseudotyping or display of complement inhibitors can inhibit complement attack ef-ficiently.This will signiflcantly increase the possibility of using baculovirus vectors for thera-peutic applications.
%K Baculoviruses
%K AcMNPV
%K Complement
%K Gene delivery<br>杆状病毒
%K AcMNPV
%K 补体
%K 基因传递
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=78024727B5F4EF6AA9CA8E605B5FC464&aid=3CFA6944303655A8A5D1BD7AEE85E15E&yid=99E9153A83D4CB11&vid=7C3A4C1EE6A45749&iid=DF92D298D3FF1E6E&sid=66156A49F03BF135&eid=C368DFEE1EA2C91D&journal_id=0253-2654&journal_name=微生物学通报&referenced_num=0&reference_num=0