Transdermal Behavior of Geniposide in Shangyi Aerosol in vivo and in vitro
彝族药伤益气雾剂中栀子苷透皮吸收的动力学观察

The transdermal behavior of geniposide was observed by using Shangyi aerosol for mice, and of the geniposide pharmacokinetics of this aerosol was studied. The geniposide concentration was determined in vitro and in vivo by the HPLC assay. Geniposide penetrated the skin 30 min after the aerosol use, and was found distributed in the hypodermis and the blood. The penetration of geniposide showed a positive linear relation. The results showed that geniposide of Shangyi aerosol could penetrate the skin both in vivo and in vitro, and be quickly distributed in the subcutaneous tissue and blood, which shows the use potential of the aerosol in clinics.