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世界科学技术-中医药现代化 2009
Identification of Chemical and Metabolic Components of Liuwei Dihuang Pills by Ultra Fast Liquid Chromatography-Electrospray-Ion Trap-Time of Flight Mass Spectrometry
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Abstract:
Objective: To identify the chemical and metabolic components. Method: UFLC gradient elution with TOF detection in positive and negative mode. Result: 40 chemical components were identified in Liuwei Dihuang extract. 6 original component and 9 metabolites were identified in rat serum. The proposed metabolic pathway was given. Conclusion: UFLC-ESI-IT-TOF was a powerful method in the analysis of complicated TCM samples. It helps the comprehensive understanding of the chemical and metabolic components of Liuwei Dihuang Pills.
