Study of Euphorbia Kansui on Mouse Liver Function Correlated with Inflammatory Cytokines
甘遂对正常小鼠肝脏相关炎性因子表达的影响

This study was aimed to explore the action of ethanol extracts of Euphorbia kansui(E.KS) on mouse liver with inflammatory cytokines.By gastric administration with three dosages of E.KS(1.2,0.6,0.3 g/kg) for 2 h,4 h and 7 d,the serum was isolated for ALT.Real time PCR was employed for IL-β,TNFα and caspase 3.Histological assay was employed for the liver.The results showed that E.KS can increase serum ALT and upregulate mRNA express of IL1-β,after 2 hours of E.KS(1.2 g/kg) administration.But there was a negative action on caspase 3 expression.It was concluded that Euphorbia kansui has definite toxicity effect on mouse liver.This effect is mainly related to the inflammatory injury.The effect is not obvious related to apoptosis.