%0 Journal Article
%T Study of Euphorbia Kansui on Mouse Liver Function Correlated with Inflammatory Cytokines<br>甘遂对正常小鼠肝脏相关炎性因子表达的影响
%A Lu Xi
%A Lei Fan
%A Xing Dongming
%A Wang Yugang
%A Xiao Xinyue
%A Hu Jun
%A Cheng Xianlong
%A Chai Yushuang
%A Feng Tianshi
%A Du Lijun
%A <br>卢希
%A 雷帆
%A 邢东明
%A 王玉刚
%A 肖新月
%A 胡珺
%A 程显隆
%A 柴玉爽
%A 冯天师
%A 杜力军
%J 世界科学技术-中医药现代化
%D 2012
%I 
%X This study was aimed to explore the action of ethanol extracts of Euphorbia kansui(E.KS) on mouse liver with inflammatory cytokines.By gastric administration with three dosages of E.KS(1.2,0.6,0.3 g/kg) for 2 h,4 h and 7 d,the serum was isolated for ALT.Real time PCR was employed for IL-β,TNFα and caspase 3.Histological assay was employed for the liver.The results showed that E.KS can increase serum ALT and upregulate mRNA express of IL1-β,after 2 hours of E.KS(1.2 g/kg) administration.But there was a negative action on caspase 3 expression.It was concluded that Euphorbia kansui has definite toxicity effect on mouse liver.This effect is mainly related to the inflammatory injury.The effect is not obvious related to apoptosis.
%K Euphorbia kansui
%K liver
%K IL-β
%K TNFα
%K caspase3
%K ALT<br>甘遂
%K 肝脏
%K IL-β
%K TNFα
%K Caspase3
%K ALT
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=B5F35A1FC27C1FF7&jid=44257A35316DB0727BA6BC707B9EDAAB&aid=0B63987600F2A39C06E16EFC3FA7330C&yid=99E9153A83D4CB11&vid=F3583C8E78166B9E&iid=38B194292C032A66&sid=FDDE90F0514924E3&eid=EDB2C8F3B92E3D13&journal_id=1674-3849&journal_name=世界科学技术-中医药现代化&referenced_num=0&reference_num=0