Research Progress in the Low-Dose Effects of Environmental Endocrine Disrupting Chemicals
环境内分泌干扰物低剂量-效应研究进展

Recently, the low-dose effects of environmental endocrine disrupting chemicals(EDCs)have become a hot topic within the environmental scientific community. The findings of low-dose(near or below its NOAEL)effects, as well as the non-monotonic dose-response relationship are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high dose testing to predict responses at the much lower environmentally relevant doses which are within the range of current exposures to numerous chemicals in wildlife and humans. In addition, the exposures to environmental endocrine disrupting chemicals are characterized by low-dose and long-term, so, it's necessary to elucidate the low-dose effects and assess the risk of the consequence on health in a scientific way.