%0 Journal Article
%T Research Progress in the Low-Dose Effects of Environmental Endocrine Disrupting Chemicals<br>环境内分泌干扰物低剂量-效应研究进展
%A WEI Li
%A ZHANG Hong-chang
%A ZHANG Ai-qian
%A YIN Da-qiang
%A <br>卫立
%A 张洪昌
%A 张爱茜
%A 尹大强
%J 生态毒理学报
%D 2007
%I 
%X Recently, the low-dose effects of environmental endocrine disrupting chemicals(EDCs)have become a hot topic within the environmental scientific community. The findings of low-dose(near or below its NOAEL)effects, as well as the non-monotonic dose-response relationship are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high dose testing to predict responses at the much lower environmentally relevant doses which are within the range of current exposures to numerous chemicals in wildlife and humans. In addition, the exposures to environmental endocrine disrupting chemicals are characterized by low-dose and long-term, so, it's necessary to elucidate the low-dose effects and assess the risk of the consequence on health in a scientific way.
%K environmental endocrine disrupting chemicals
%K low-dose effects
%K dose-response relationship
%K risk assessment<br>环境内分泌干扰物
%K 低剂量-效应
%K 剂量-效应关系
%K 风险评价
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=BEC1F4700DD66C14D137590A0896A0AD&jid=B98D390DF92C35E6DD1987675E4EE86E&aid=A04305529A122535&yid=A732AF04DDA03BB3&vid=0B39A22176CE99FB&iid=CA4FD0336C81A37A&sid=C5154311167311FE&eid=4AD960B5AD2D111A&journal_id=1673-5897&journal_name=生态毒理学报&referenced_num=5&reference_num=24