ALUMINUM PHTHALOCYANINE: A STUDY OF ITS LTTATE AND PHOTOCYTOTOXICITY IN HUMAN CANCER CELLS
铝酞菁:人癌细胞的吸收及光敏杀伤的研究

The different of cellular uptake and photocytotoxicity of sulfonated aluminum phtralocyanine I AISPC and haematoporphyrin cerinative HPD were investigated Some factors, such as photosensitizer's distribution in cells, the amount of cell -associated photosensitizer, the serum's effect and the kinetics of cellular uptake be studied The results showed that, besides the similar characteristics of two photosensitizers, the speed of AISPC uptake of cells is slower than that of HPD uptake. Experiments of photosensitization exhibited that, when irradiated with red light, the photodamaging effects on cells of both photosensitizers are close to each other; but when exposed to room light the cytotoxic effect of AISPC is lower than that of HPD, suggesting a potential advantage of reducing undesired side effects in clinical application.