%0 Journal Article
%T ALUMINUM PHTHALOCYANINE: A STUDY OF ITS LTTATE AND PHOTOCYTOTOXICITY IN HUMAN CANCER CELLS<br>铝酞菁:人癌细胞的吸收及光敏杀伤的研究
%A 陈暨耀
%A 蔡怀新
%A 闵红波
%A 吕发度
%A 余宏宇
%A 董荣春
%J 生物物理学报
%D 1990
%I 
%X The different of cellular uptake and photocytotoxicity of sulfonated aluminum phtralocyanine I AISPC and haematoporphyrin cerinative HPD were investigated Some factors, such as photosensitizer's distribution in cells, the amount of cell -associated photosensitizer, the serum's effect and the kinetics of cellular uptake be studied The results showed that, besides the similar characteristics of two photosensitizers, the speed of AISPC uptake of cells is slower than that of HPD uptake. Experiments of photosensitization exhibited that, when irradiated with red light, the photodamaging effects on cells of both photosensitizers are close to each other; but when exposed to room light the cytotoxic effect of AISPC is lower than that of HPD, suggesting a potential advantage of reducing undesired side effects in clinical application.
%K 癌细胞
%K 铝酞菁
%K 吸收
%K 光敏杀伤
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=9071DA114C53C31FB8FCD7B29845E3CC&yid=8D39DA2CB9F38FD0&vid=B31275AF3241DB2D&iid=E158A972A605785F&sid=BA48F0B914ED890A&eid=389DA78D878702A9&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=2&reference_num=2