Oxidative Damage of Bisphenol A to Mouse Hepatic and Nephric Cells in Vivo
双酚A对小鼠肝脏和肾脏细胞的氧化损伤

To investigate the oxidative toxicity of bisphenol A (BPA), Kunming male mice were fed daily with BPA at the doses of 20, 40 and 80 mg·kg-1·d-1 for one week. The reactive oxygen species (ROS) level, glutathione (GSH) content, malondialdehyde (MDA) content and DNA-protein cross-linking (DPC) coefficient of hepatocytes and nephrocytes were detected to estimate the oxidative stress in the liver and kidney of male mice. Compared with the control, ROS generation, MDA content and DPC coefficient increased while GSH content decreased in BPA exposure groups (P<0.05 or P<0.01). ROS level, GSH content and DPC coefficient all showed dose-effect relationships. It is demonstrated that BPA could induce oxidative damage by disturbing the balance between ROS and antioxidant defense system in liver and kidney of mice.