%0 Journal Article
%T Oxidative Damage of Bisphenol A to Mouse Hepatic and Nephric Cells in Vivo<br>双酚A对小鼠肝脏和肾脏细胞的氧化损伤
%A Fu Yu
%A Wang Huiyu
%A Ke Chenjuan
%A Wang Jingming
%A Xiong Guomei
%A Yang Xu
%A <br>付宇
%A 王慧玉
%A 可尘娟
%A 王景明
%A 熊国梅
%A 杨旭
%J 生态毒理学报
%D 2012
%I 
%X To investigate the oxidative toxicity of bisphenol A (BPA), Kunming male mice were fed daily with BPA at the doses of 20, 40 and 80 mg·kg-1·d-1 for one week. The reactive oxygen species (ROS) level, glutathione (GSH) content, malondialdehyde (MDA) content and DNA-protein cross-linking (DPC) coefficient of hepatocytes and nephrocytes were detected to estimate the oxidative stress in the liver and kidney of male mice. Compared with the control, ROS generation, MDA content and DPC coefficient increased while GSH content decreased in BPA exposure groups (P<0.05 or P<0.01). ROS level, GSH content and DPC coefficient all showed dose-effect relationships. It is demonstrated that BPA could induce oxidative damage by disturbing the balance between ROS and antioxidant defense system in liver and kidney of mice.
%K bisphenol A
%K Kuming mice
%K reactive oxygen species (ROS)
%K glutathione (GSH)
%K malondialdehyde (MDA)
%K DNA-protein cross-linking coefficient (DPC)
%K oxidative damage<br>双酚A
%K 昆明小鼠
%K 活性氧
%K 还原型谷胱甘肽
%K 丙二醛
%K DNA蛋白质交联系数
%K 氧化损伤
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=3FF3ABA7486768130C3FF830376F43B398E0C97F0FF2DD53&cid=BEC1F4700DD66C14D137590A0896A0AD&jid=B98D390DF92C35E6DD1987675E4EE86E&aid=ED552BFB92CBE65FB55C4C3B90A2683C&yid=99E9153A83D4CB11&vid=DF92D298D3FF1E6E&iid=E158A972A605785F&sid=5DCBAAB000A70168&eid=2E41258BCB9A7DB2&journal_id=1673-5897&journal_name=生态毒理学报&referenced_num=0&reference_num=0