THE ~1H-NMR INVESTIGATION OF CONTORMATIONAL CHANGES IN THE GENOME DNA OF ASCITES CANCEROUS MOUSE
S_(180)肉瘤细胞对小鼠基因组DNA结构变化影响的核磁共振氢谱~1H—NMR研究

In order to study the DNA conformational changes in different cancer culture time, a 1H-NMR spectrum investigation of DNA was conducted. While extending the cancer culture time. the chemical environmental conditions around DNA were changed. It caused the DNA molecule to adopt the different conformation . We found that some methylic protons of thymidylic acid in DNA shifted downfield so that the area of peak I fat 1.9ppm) was reduced, but peak II (at 2.6-2.7ppm proton spectral region) increased The result showed that the area rate of the two peaks (Peak I Peak II) was reduced dramatically. This is a new method to investigate the genetic principle of carcinogenesis.