%0 Journal Article
%T THE ~1H-NMR INVESTIGATION OF CONTORMATIONAL CHANGES IN THE GENOME DNA OF ASCITES CANCEROUS MOUSE<br>S_(180)肉瘤细胞对小鼠基因组DNA结构变化影响的核磁共振氢谱~1H—NMR研究
%A 陈立奇
%A 乔梁
%A 苏宁
%A 黄丽茹
%A 王戈华
%A 柳家英
%A 张效良
%J 生物物理学报
%D 1990
%I 
%X In order to study the DNA conformational changes in different cancer culture time, a 1H-NMR spectrum investigation of DNA was conducted. While extending the cancer culture time. the chemical environmental conditions around DNA were changed. It caused the DNA molecule to adopt the different conformation . We found that some methylic protons of thymidylic acid in DNA shifted downfield so that the area of peak I fat 1.9ppm) was reduced, but peak II (at 2.6-2.7ppm proton spectral region) increased The result showed that the area rate of the two peaks (Peak I Peak II) was reduced dramatically. This is a new method to investigate the genetic principle of carcinogenesis.
%K H-spectrum Nuclear Magnetic Resonance (1H-NMR)
%K Proto - oncogene
%K Sarcoma -180(S- 180)
%K cell
%K The area rate of the two peaks Peak integrating area Peak II integrating area
%K H-H Two Dimensional Nudear Overhouse Effect (Two -D NOE) related spectru<br>肿瘤细胞
%K 基因组
%K DNA
%K 核磁共振氢谱
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=C9BBC44F0FE9543830E94DA1188FCF49&yid=8D39DA2CB9F38FD0&vid=B31275AF3241DB2D&iid=0B39A22176CE99FB&sid=30897FA31CA3354D&eid=4FE459D71E3BF8EB&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=1&reference_num=0