THE EFFECTS OF INTERACTIONS IN BILAYER LIPID MEMBRANES (BLM)ON ITS ELECTRICAL PROPERTIES
膜上相互作用对平板双分子层脂膜电性质的影响

Drug-biomembrane interaction was studied by measuring the electrical properties of bilayer lipid membranes(BLM) as a simple model of biomembranes. The typical substances-surfactants, radical and metallic chiral complexes caused regular changes of membrane electrical parameters. The specific interaction between the reassembled type-B human erythrocyte membranes and its ligand, anti-B monoclonal antibody, caused a rapid decrease in membrane resistance(Rm) and membrane breakdown finally. The magnitude of Rm decrease is positively related to the amount of antibody added. This suggests that BLM can be a useful instrument to study drug-membrane interaction and drug permeation, by measuring and analyzing its electrical parameters.