%0 Journal Article
%T THE EFFECTS OF INTERACTIONS IN BILAYER LIPID MEMBRANES (BLM)ON ITS ELECTRICAL PROPERTIES<br>膜上相互作用对平板双分子层脂膜电性质的影响
%A ZHANG Yu-feng
%A WANG Li
%A HOU Xin-pu
%A <br>张宇锋
%A 王黎
%A 侯新朴
%J 生物物理学报
%D 2000
%I 
%X Drug-biomembrane interaction was studied by measuring the electrical properties of bilayer lipid membranes(BLM) as a simple model of biomembranes. The typical substances-surfactants, radical and metallic chiral complexes caused regular changes of membrane electrical parameters. The specific interaction between the reassembled type-B human erythrocyte membranes and its ligand, anti-B monoclonal antibody, caused a rapid decrease in membrane resistance(Rm) and membrane breakdown finally. The magnitude of Rm decrease is positively related to the amount of antibody added. This suggests that BLM can be a useful instrument to study drug-membrane interaction and drug permeation, by measuring and analyzing its electrical parameters.
%K Bilayer lipid membranes(BLM)
%K Membrane electrical properties
%K Surfactant
%K Hydroxyl radical
%K Metallic chiral complexes
%K Receptor-ligand interacti<br>平板双分子层脂膜
%K 膜电性质
%K 两新性物质
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=E0C9D9BBED813D6674AC13E942EAC86D&aid=566303DEB0431CBB&yid=9806D0D4EAA9BED3&vid=7801E6FC5AE9020C&iid=E158A972A605785F&sid=D02611D1F8166C9A&eid=27A3D4EE1F52A91C&journal_id=1000-6737&journal_name=生物物理学报&referenced_num=7&reference_num=5