EFFECTS OF ANISODAMINE ON THE MOTION OF PROTEINS AND LIPIDS IN HUMAN ERYTHROCYTE MEMBRANES
山莨菪碱对人红细胞膜蛋白及膜脂运动的影响

The effects of anisodamine on the motion of proteins and lipids in human erythrocyte membranes have been studied with spin label EPR. The FPR spectra of proteins of anisodamine-treated erythrocyte membranes labeled with maleimide shows that the ratio of strongly immobilized to weakly immobilized components is increased as compared with control, and the motion of the proteins of erythrocyte membranes are restricted. The anisodamine interacts mainly with the polar head of the membrane lipid and affects the membrane fluidity. The possible mechanism of anisodamine-membrane interaction has been discussed.