Theoretical Evaluation on Antioxidant Activity of Components from Four Herbs
对九种天然产物清除自由基活性的理论评价

Employing quantum chemistry method,the O-H bond dissociation enthalpies (BDEs) and ionization potentials (IPs) of nine natural products,scutellarin,pyromeconic acid,3,5-Dicafferoylquinic acid,erigoster B,salvianolic acid B,salviamiltiorrhiza,bioflavones,ginkgolides B,hydroxysafflor yellow A,extracted from four herbs,Erigeron brevisecapus Hand.Mazz,Salvia miltiorrhiza Bunge,Ginkgo biloba Linn and Carthamus tinctorius L,were calculated.Accordingly,the radical-scavenging activity of these components was evaluated.It was found that 3,5-dicafferoylquinic acid,erigoster B,salvianolic acid B and salviamiltiorrhiza were rather active to scavenge free radicals in non-polar solvents,while breviscap-ine B held much higher antioxidant activity than that of other eight components in polar solvent,which indicated that these compounds are promising to be developed as efficient drugs to treat radical-induced cardiovascular and cerebrovascular diseases.