Solution structure and antibacterial mechanism of two synthetic antimicrobial peptides
两种合成抗菌肽的结构及抗菌作用机理

Mytilin-derived-peptide-1(MDP-1) and mytilin-derived-peptide-2(MDP-2) are two truncated decapeptides with reversed sequence synthesized corresponding to the residues 20-29 of mytilin-1(GenBank Accession No.FJ973154) from M.coruscus.The objective of this study is to characterize the structural basis of these two peptides for their antimicrobial activities and functional differences,and to investigate the inhibitory mechanism of MDPs on Escherichia coli and Sarcina lutea.The structures of MDP-1 and MDP-2 in s...