DNA-PKcs silencing inhibit the DNA repair induced by low dose radiation on human breast epithelial cells
DNA-PKcs基因沉默抑制人乳腺上皮细胞对低剂量辐射损伤的修复

DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase(DNA-PK), plays an important role in the nonhomologous end-joining(NHEJ) pathway of DNA double-strand breaks(DSBs) repair.To investigate the effects of DNA-PKcs down-regulation on cell growth and sensitization to low dose radiation(LDR), we transfected DNA-PKcs siRNA into human mammary epithelia cells MCF10F, then, detected the proliferation curve of the cells and the expression of protiens in DNA repair pathways.The results showed that DNA-PKcs...