%0 Journal Article
%T DNA-PKcs silencing inhibit the DNA repair induced by low dose radiation on human breast epithelial cells<br>DNA-PKcs基因沉默抑制人乳腺上皮细胞对低剂量辐射损伤的修复
%A Wei Zou
%A Jian Che
%A Chongjie Wang
%A Yuying Cui
%A Qinming Zhang
%A <br>邹伟
%A 车鉴
%A 王崇杰
%A 崔玉影
%A 张钦明
%J 生物工程学报
%D 2009
%I 
%X DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase(DNA-PK), plays an important role in the nonhomologous end-joining(NHEJ) pathway of DNA double-strand breaks(DSBs) repair.To investigate the effects of DNA-PKcs down-regulation on cell growth and sensitization to low dose radiation(LDR), we transfected DNA-PKcs siRNA into human mammary epithelia cells MCF10F, then, detected the proliferation curve of the cells and the expression of protiens in DNA repair pathways.The results showed that DNA-PKcs...
%K breast epithelial cell line
%K gene silence
%K DNA-PKcs gene<br>乳腺细胞
%K 基因沉默
%K DNA-PKcs基因
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=0422FAFCE6204017B61B148BFCB22B5F&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=94C357A881DFC066&sid=0EE24608F5763811&eid=20D29EF591CB2C94&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=1&reference_num=22