Discriminating acidic, neutral and alkaline enzymes with secondary structure amino acid composition
基于二级结构氨基酸组成识别酸性、中性及碱性酶

In this work, we systematically analyzed the secondary structure amino acid compositions of acidic and alkaline enzymes and compared them with neutral ones. We found that the propensity of the individual residues to participate in secondary structures and the consistently higher composition of neutral and tiny residues might be the general stability mechanisms for their adaptation to pH extremes. Based on this, we presented a secondary structure amino acid composition method for extracting useful features f...