%0 Journal Article
%T Discriminating acidic, neutral and alkaline enzymes with secondary structure amino acid composition<br>基于二级结构氨基酸组成识别酸性、中性及碱性酶
%A Guangya Zhang
%A Jiaqiang Gao
%A Baishan Fang
%A <br>张光亚
%A 高嘉强
%A 方柏山
%J 生物工程学报
%D 2009
%I 
%X In this work, we systematically analyzed the secondary structure amino acid compositions of acidic and alkaline enzymes and compared them with neutral ones. We found that the propensity of the individual residues to participate in secondary structures and the consistently higher composition of neutral and tiny residues might be the general stability mechanisms for their adaptation to pH extremes. Based on this, we presented a secondary structure amino acid composition method for extracting useful features f...
%K secondary structure
%K amino acid composition
%K acidic enzyme
%K alkaline enzyme
%K mechanism of stability
%K feature extraction
%K random forests<br>二级结构
%K 氨基酸组成
%K 酸性酶
%K 碱性酶
%K 稳定性机制
%K 特征提取
%K 随机森林
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=90BA3D13E7F3BC869AC96FB3DA594E3FE34FBF7B8BC0E591&jid=A66E90C274451689E69F6F0291467824&aid=CE97A5419FEB253F2CCC736949E365B6&yid=DE12191FBD62783C&vid=C5154311167311FE&iid=F3090AE9B60B7ED1&sid=D80AE3757B45ED33&eid=6F185A924223F19E&journal_id=1000-3061&journal_name=生物工程学报&referenced_num=0&reference_num=0