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生物工程学报 2012
Autophagy and Caveolin-1 in cancer: a review
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Abstract:
Autophagy, is an essential cellular process involving self-degradation of intracellular components via the lysosome, which plays the Janus role in cancer initiation and progression. Caveolin-1, a marker protein of caveolae, functions as scaffolding protein mediating many physiological and pathological processes including caveolae biogenensis, vesicular transport, cholesterol homeostasis, signal transduction and tumorigenesis. Recently, many reports showed that autophagy of tumor cells associated with stromal Cav-1. In this article, we reviewed the role of autophagy and relationship with Cav-1 in tumorigenesis and cancer development.
