MODELING STUDY IN THE PARTIAL-FLEXIBLE DOUBLE HELICAL CONFORMATION OF NUCLEIC ACIDS
部分柔性的核酸双螺旋构象的模型化研究

From the basic idea of the structural units of nucleic acids, through analyzing and simplifying the freedom set of an arbitrary base-pair-number DNA fragment, the DNA/m5cDNA/RNA double helical models have been built, and the algorithm for partial-flexible two-base-pair model has been created. With this method, the conformational parameters of B-form DNA being; consistent with the experimental data have been given. In terms of the ststistical limitation of DNA intercalating acceptors got from experiments, three-pase-pair DNA acceptors suitable for the intercalators of Adriamycin and its derivatives have been built and refined.